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RegisterNo random calibrators (and QCs) [Bioanalytics]
posted by Helmut 
– Vienna, Austria, 2019-02-02 16:49 (2237 d 08:05 ago) – Posting: # 19846
Views: 3,220
Hi Bert,
Not that I recall. I agree with ElMaestro’s comments.
Not a good idea – even if there is no substantial carry-over (see the EMA’s GL Section 4.2.2). If you decide to inject calibrators at the start and end of the batch do so with increasing concentrations which minimizes the relative impact of carry-over. If you have calibrators within the set of unknown samples inject a blank after. The same is applicable for QC samples as well.
Not referring to your age or experience but the number of posts in the forum.
❝ Is there any guidance for the location of calibration samples in an analytical run?
Not that I recall. I agree with ElMaestro’s comments.
❝ Should this be at-random?
Not a good idea – even if there is no substantial carry-over (see the EMA’s GL Section 4.2.2). If you decide to inject calibrators at the start and end of the batch do so with increasing concentrations which minimizes the relative impact of carry-over. If you have calibrators within the set of unknown samples inject a blank after. The same is applicable for QC samples as well.
❝ (Like it, called Junior 
)
Not referring to your age or experience but the number of posts in the forum.
Junior : <25
Regular: 25 < 100
Senior : 100 < 500
Hero : >500—
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Helmut Schütz
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Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Complete thread:
- random calibration samples Bert 2019-01-24 14:14 [Bioanalytics]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- random calibration samples ElMaestro 2019-01-24 17:11
- No random calibrators (and QCs)Helmut 2019-02-02 15:49
- No random calibrators (and QCs) Bert 2019-02-04 08:20
Ing. Helmut Schütz