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Hi,
if you don't have analytical solution - look for simulations approach
Simulate the data using known distribution parameters, desired sample size and then use bootstrap technique for evaluation. Repeat it ad-hoc (until the success/failure ratio stabilizes). Then change the sample size and repeat until desired power is reached. Don't forget about SciAdv.
if you don't have analytical solution - look for simulations approach
Simulate the data using known distribution parameters, desired sample size and then use bootstrap technique for evaluation. Repeat it ad-hoc (until the success/failure ratio stabilizes). Then change the sample size and repeat until desired power is reached. Don't forget about SciAdv.
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Kind regards,
Mittyri
Kind regards,
Mittyri
Complete thread:
- Sample Size calculation for ophthalmic PK endpoint study CBB 2019-01-30 12:06 [Power / Sample Size]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Simulations?mittyri 2019-01-31 23:28
Ing. Helmut Schütz