fAUC0-24 / MIC index [PK / PD]

posted by mittyri – Russia, 2019-01-31 23:12 (912 d 03:47 ago) – Posting: # 19835
Views: 1,465

(edited by mittyri on 2019-01-31 23:40)

Hi,

I'm not involved with antimicrobial stuff, but from my PK/PD understanding if the steady state is reached, the AUC won't change over different dose intervals (except of course some interoccasion variability).
So if for dose interval 8h you propose that AUCss0-8 equals to AUCss8-16, you can just multiply it to get an average value:
AUCss0-24 = AUCss0-8 * 3

Assumptions are:
- steady state
- no autoinduction or other time-varying parameters

Kind regards,
Mittyri

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