PK/PD Index [PK / PD]

posted by PKBR – Brazil, 2019-01-30 14:38  – Posting: # 19829
Views: 336

(edited by mittyri on 2019-01-30 16:28)

Dear all,

The PK / PD indexes are already well discussed in the literature, although they still present divergent points about the best index to be used for a given antimicrobial.

When we use the fAUC0-24 / MIC index, we have the concentration determined for 24 hours in single dose studies. But when we use only multi-dose antimicrobial in clinical practice, for example, every 6 or 8 or 12 hours, how can we evaluate this index if it mentions 0-24? Or should we do the collection experiment for 24 hours, even if this interval in no way represented sufficient exposure in the clinic? How can we evaluate this Pk/PD index for multiple dosing with intervals shorter than 24/24 hr? I'm confused. Could someone clarify this?

Thank you very much.


Edit: Category changed; see also this post #1. [Mittyri]
Please verify that category is right before posting!

Complete thread:

Activity
 Mix view
Bioequivalence and Bioavailability Forum |  Admin contact
19,405 posts in 4,122 threads, 1,323 registered users;
online 6 (0 registered, 6 guests [including 3 identified bots]).
Forum time (Europe/Vienna): 07:08 CEST

[Those] who have an excessive faith in their theories or in their
ideas are not only poorly disposed to make discoveries, but they
also make very poor observations.    Claude Bernard

The BIOEQUIVALENCE / BIOAVAILABILITY FORUM is hosted by
BEBAC Ing. Helmut Schütz
HTML5