Simulation plasma and tissue profile [PK / PD]

posted by PKBR – Brazil, 2019-01-30 01:58  – Posting: # 19825
Views: 314

(edited by mittyri on 2019-01-30 12:50)

I'd like to ask about simulation.
1. I have one dose data (named D1, single dose) from plasma (total concentration) and from tissue (free concentration), as well as data from another dose (named D2, multiple dose) for tissue but not for plasma. After non-compartmental analysis of the data, there was no statistically significant difference for half-life between plasma (D1) and tissue (D1 and D2) by ANOVA. AUC / Dose by D1 and D2 also had no difference. Given the value of binding to plasma proteins and having the free concentration profiles for D1 and D2, would it be possible to calculate the total plasma concentration of D2 for each point, considering the free concentration in this dose at each time?

2. If it is possible, and with total plasma concentration profile projected for D2, could we use compartmental analysis and, following two compartments, obtain A, B, alpha and beta macro-constants? From this point on, could we simulate other multiple dosing schedules (changing the interval between doses)?

I do not know if it is possible to make these assumptions ... could anyone clarify these questions?

Kind regards!

Edit: Category changed; see also this post #1. [Mittyri]

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