## AUCinf, MRT, Partial AUC [Software]

❝ When we do NCA we have obs and pred parameters. Which is better to use? Ex: AUCobs or AUCpred?

❝ When we do plasma and microdialysate experiments, but the time collections are not the same, for example, plasma collections was performed until 9 hr and microdialysis collections in tissue until 8.5 hr. Is it possible to compare the MRT in this case with different time of experiment?

In WNL wordings

**MRTlast = AUMClast/AUClast**(bolus case)

If the coverage of PK profile is enough, the estimation of MRT would be fair enough too.

❝ What about AUC? For AUC would be possible to extrapolate the concentration up to 9hr considering the k?

❝ When we calculate t1/2 and MRT after iv bolus dosing and these values are different, which could be the reasons if the k is not statistically different?

Thus since HL = ln(2)/kel

the distribution of parameters won't be the same.

Simple example in R

`> t.test(1:10, y = c(7:20)) `

Welch Two Sample t-test

data: 1:10 and c(7:20)

t = -5.4349, df = 21.982, p-value = 1.855e-05

alternative hypothesis: true difference in means is not equal to 0

95 percent confidence interval:

-11.052802 -4.947198

sample estimates:

mean of x mean of y

5.5 13.5

> t.test(log(2)/1:10, y = c(log(2)/7:20))

Welch Two Sample t-test

data: log(2)/1:10 and c(log(2)/7:20)

t = 2.3964, df = 9.1376, p-value = 0.03974

alternative hypothesis: true difference in means is not equal to 0

95 percent confidence interval:

0.008506605 0.283884254

sample estimates:

mean of x mean of y

0.20302061 0.05682518

Kind regards,

Mittyri

### Complete thread:

- Phoenix Winnonlin PKBR 2019-01-25 18:27 [Software]
- AUCinf, MRT, Partial AUCmittyri 2019-01-26 22:42
- AUCinf, MRT, Partial AUC PKBR 2019-01-28 18:54

- AUCinf, MRT, Partial AUCmittyri 2019-01-26 22:42