Bioequivalence and Bioavailability Forum • Phoenix Winnonlin

Phoenix Winnonlin [Software]

posted by PKBR – Brazil, 2019-01-25 18:27 (1042 d 07:42 ago) – Posting: # 19809
Views: 2,362

Dear all,

I just have quick questions for you all - quite basic.

When we do NCA we have obs and pred parameters. Which is better to use? Ex: AUCobs or AUCpred?
When we do plasma and microdialysate experiments, but the time collections are not the same, for example, plasma collections was performed until 9 hr and microdialysis collections in tissue until 8.5 hr. Is it possible to compare the MRT in this case with different time of experiment? What about AUC? For AUC would be possible to extrapolate the concentration up to 9hr considering the k?
When we calculate t1/2 and MRT after iv bolus dosing and these values are different, which could be the reasons if the k is not statistically different?

Many thanks,
PKBR.

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Phoenix WinnonlinPKBR 2019-01-25 18:27 [Software]
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