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Interference from Deuterated IS [Bioanalytics]

posted by ElMaestro - Denmark, 2019-01-11 09:49  - Posting: # 19773
Views: 182

Hello chirag,

may I ask:

» 2.During method development we observed around 12-16% interference from Digoxin deuterated (D3) IS at the RT of Digoxin drug. There seems to be no source for D5 or D7 or D11.

Does the IS increase or decrease the area of the analyte?

» 4. Two different sources of Deuterated IS were tested and results are similar.

What is the purity expressed as DigD3 on your CoA's?

if (3) 4

Best regards,
ElMaestro

"(...) targeted cancer therapies will benefit fewer than 2 percent of the cancer patients they’re aimed at. That reality is often lost on consumers, who are being fed a steady diet of winning anecdotes about miracle cures." New York Times (ed.), June 9, 2018.

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