Bioequivalence and Bioavailability Forum • Calculation of time above MIC

Calculation of time above MIC [🇷 for BE/BA]

posted by Helmut – Vienna, Austria, 2008-06-27 02:18 (5774 d 20:22 ago) – Posting: # 1977
Views: 32,996

Dear Ace,

I’m too tired to fire up R and check your code, but here’s a second quickshot in Excel – I didn’t save my R-code and wanted to get an independent solution.
We have three segments in the profile above the threshold (I inserted conc=0 at t=0).

Segment 1:   0.404 →  21.96 (delta  21.56)

Segment 2:  25.34  → 106.96 (delta  81.61)

Segment 3: 109.08  → 122.42 (delta  13.34)

                             total 116.51…

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz

The quality of responses received is directly proportional to the quality of the question asked. 🚮
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Complete thread:

Calculation of time above MIC Aceto81 2008-06-26 16:31
- Calculation of time above MIC Helmut 2008-06-26 18:58
  - Calculation of time above MIC Aceto81 2008-06-26 21:50
    - Calculation of time above MICHelmut 2008-06-27 00:18
    - Calculation of time above MIC Helmut 2008-06-29 02:24
      - Calculation of time above MIC Aceto81 2008-06-30 15:50
        
        Therapeutic Occupancy Time / MEC Helmut 2008-06-30 16:45
  - Time above MIC (WinNonlin 5.2.1) Helmut 2008-08-08 20:38
    - Time above MIC (WinNonlin 5.2.1) Aceto81 2008-08-12 09:56
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        Time above MIC (R function) Aceto81 2008-08-13 11:19
        
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