Interference from Deuterated IS [Bioanalytics]

posted by Ohlbe – France, 2019-01-10 23:36 (2015 d 03:00 ago) – Posting: # 19769
Views: 3,628

Dear VKB2207,

❝ You can probably evaluate the % contribution from IS at RT of drug


Sure. It's called the intercept :-D

❝ and then apply this factor in CC, QC nominal concentrations.


Certainly not. It is taken into consideration when calculating the calibration curve parameters, unless you are forcing the intercept through 0 (which is not to be done in bioanalysis).

❝ Hence measured concentrations would be inaccurate.


Not necessarily at high level of concentrations. Could indeed be problematic closer to the LLOQ.

Regards
Ohlbe

Complete thread:

UA Flag
Activity
 Admin contact
23,107 posts in 4,858 threads, 1,644 registered users;
64 visitors (0 registered, 64 guests [including 8 identified bots]).
Forum time: 03:37 CEST (Europe/Vienna)

All paid jobs absorb and degrade the mind.    Aristotle

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5