Bioequivalence and Bioavailability Forum 07:51 CET

Main page Policy/Terms of Use Abbreviations Latest Posts

 Log in |  Register |  Search

Interference from Deuterated IS [Bioanalytics]

posted by Ohlbe - France, 2019-01-10 22:36  - Posting: # 19769
Views: 216

Dear VKB2207,

» You can probably evaluate the % contribution from IS at RT of drug

Sure. It's called the intercept :-D

» and then apply this factor in CC, QC nominal concentrations.

Certainly not. It is taken into consideration when calculating the calibration curve parameters, unless you are forcing the intercept through 0 (which is not to be done in bioanalysis).

» Hence measured concentrations would be inaccurate.

Not necessarily at high level of concentrations. Could indeed be problematic closer to the LLOQ.

Regards
Ohlbe

Complete thread:

Activity
 Mix view
Bioequivalence and Bioavailability Forum |  Admin contact
19,016 posts in 4,056 threads, 1,297 registered users;
online 17 (1 registered, 16 guests [including 12 identified bots]).

The only people who see the whole picture are the ones
who step out of the frame.    Salman Rushdie

The BIOEQUIVALENCE / BIOAVAILABILITY FORUM is hosted by
BEBAC Ing. Helmut Schütz
HTML5 RSS Feed