Interference from Deuterated IS [Bioanalytics]

posted by Ohlbe – France, 2019-01-10 22:36  – Posting: # 19769
Views: 621

Dear VKB2207,

» You can probably evaluate the % contribution from IS at RT of drug

Sure. It's called the intercept :-D

» and then apply this factor in CC, QC nominal concentrations.

Certainly not. It is taken into consideration when calculating the calibration curve parameters, unless you are forcing the intercept through 0 (which is not to be done in bioanalysis).

» Hence measured concentrations would be inaccurate.

Not necessarily at high level of concentrations. Could indeed be problematic closer to the LLOQ.

Regards
Ohlbe

Complete thread:

Activity
 Mix view
Bioequivalence and Bioavailability Forum |  Admin contact
19,302 posts in 4,102 threads, 1,316 registered users;
online 4 (1 registered, 3 guests [including 4 identified bots]).

Restlessness is discontent –
and discontent is the first necessity of progress.
Show me a thoroughly satisfied man –
and I will show you a failure.    Thomas Alva Edison

The BIOEQUIVALENCE / BIOAVAILABILITY FORUM is hosted by
BEBAC Ing. Helmut Schütz
HTML5