Interference from Deuterated IS [Bioanalytics]

posted by VKB2207 – Portugal, 2019-01-10 20:48  – Posting: # 19767
Views: 623

Hi,

Suggest you not to go with MV in this scenario as IS is contributing and you have no exact idea how much it is contributing. Hence measured concentrations would be inaccurate.

You can probably evaluate the % contribution from IS at RT of drug and then apply this factor in CC, QC nominal concentrations.

Hope it helps.

Regards


Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post! [Ohlbe]

Complete thread:

Activity
 Mix view
Bioequivalence and Bioavailability Forum |  Admin contact
19,302 posts in 4,102 threads, 1,316 registered users;
online 5 (1 registered, 4 guests [including 4 identified bots]).

Restlessness is discontent –
and discontent is the first necessity of progress.
Show me a thoroughly satisfied man –
and I will show you a failure.    Thomas Alva Edison

The BIOEQUIVALENCE / BIOAVAILABILITY FORUM is hosted by
BEBAC Ing. Helmut Schütz
HTML5