Power.TOST and "3x3" [R for BE/BA]

posted by ElMaestro  – Belgium?, 2019-01-08 15:29  – Posting: # 19760
Views: 2,127

Dear all,
or perhaps mainly the powerTOST authors and maintainers :-D

thanks a lot for power.TOST and related functions. They are great.

I have a question about e.g.

> power.TOST(CV=.3, theta0=.95, n=30, design="3x3")
[1] 0.6973262


Is that the chance of showing BE for one of the comparisons, for two comparisons if we assume two are tests formulations and one if ref, or is it "all against all" which is also a common comparison?

Now, I am asking because theta0 seems to be a single number, not a vector.
Imagine we have formulations A, B and C; if true ratios for A/B and B/C are 0.95 then in my little simple universe the true ratio for A/C is ~0.9. Therefore, I imagine it is not for all against all (3 comparisons in my case).

So I wonder what goes on behind the curtains in R when I give the command above and how I should interpret the output here. I read the documentation and did not see an obvious answer but I am also not so well versed with power.TOST.

Many thanks for any input.
Or output, depending on your perspective.:-D

I could be wrong, but...

Best regards,
ElMaestro

"Pass or fail" (D. Potvin et al., 2008)

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