Baseline correction method [NCA / SHAM]

posted by martin  – Austria, 2019-01-08 12:24 (690 d 17:23 ago) – Posting: # 19759
Views: 1,638

Dear MSMN,

I am not aware of a method called "elimination rate constant method" for adjustment of circulating endogenous concentrations. However, you may find this article useful:

Bauer, A. & Wolfsegger, M.J. Eur J Clin Pharmacol (2014) 70: 1465.

hope this helps


Ps.: if the pre-dose sample >LLOQ is due to a residual concentrations arising from a previous dose, then the elimination rate could be used for adjustment of post-dose concentrations under some premises.

PPS.: this topic is also mentioned in some regulatory guidelines (e.g. page 9 at

Complete thread:

 Admin contact
21,216 posts in 4,427 threads, 1,481 registered users;
online 11 (0 registered, 11 guests [including 9 identified bots]).
Forum time: Sunday 05:48 CET (Europe/Vienna)

Half the harm that is done in this world
Is due to people who want to feel important.    T. S. Eliot

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz