Bioequivalence and Bioavailability Forum

90% confidence interval for R_dnm [Study Assessment]

posted by d_labes – Berlin, Germany, 2019-01-07 19:24 (1929 d 00:33 ago) – Posting: # 19755
Views: 17,833

Dear Shuanghe,

❝ ❝ Could you please give a detailed example for what you did here?

❝

❝ Sorry. It seems I didn't explain it clearly. My SAS code is almost the same as yours:

❝

❝ PROC MIXED DATA = smith METHOD = ML;


❝   CLASS subj ;

❝   MODEL lcmax = ldose / DDFM=SATTERTHWAITE CL ALPHA = 0.1 ;

❝   RANDOM INTERCEPT / SUBJECT = subj;

❝   ODS OUTPUT solutionf = out1;

❝ RUN;

❝ ...

Thanks for your explanation. Didn't really understand but ...

Seen that you only used doses 25 and 250 for R_dnm although there are entries with doses of 50 and 75 mg. But since you are using the fitted (predicted) PK metrics it doesn't matter. And is equivalent to my suggestion.

❝ By the way, Helmut, I don't know how to make a table ...

Don't expect any reaction from Helmut before February. He is down under (New Zealand) and will return earliest at the beginning of February...

—
Regards,

Detlew

Complete thread:

Dose Proportionality and Variance AngusMcLean 2016-05-11 16:55 [Study Assessment]
- More information, please Helmut 2016-05-12 14:34
  - More information, please AngusMcLean 2016-05-13 16:40
    - Setup in Phoenix/WinNonlin Helmut 2016-05-14 02:26
      - Setup in Phoenix/WinNonlin AngusMcLean 2016-05-14 18:54
        
        Setup in Phoenix/WinNonlin Helmut 2016-05-15 14:47
        
        Setup in Phoenix/WinNonlin AngusMcLean 2016-05-15 15:17
        
        Phoenix 64 Warning Helmut 2016-05-15 15:56
        
        Phoenix 64 Warning AngusMcLean 2016-05-15 20:11
        
        OT: imperial vs. metric units Helmut 2016-05-16 16:26
        
        Setup in Phoenix/WinNonlin ElMaestro 2016-05-15 20:54
        
        Setup in Phoenix/WinNonlin AngusMcLean 2016-05-15 22:30
      - Setup in Phoenix/WinNonlin AngusMcLean 2016-05-16 21:00
        
        NCSS vs. PHX/WNL vs. SAS Helmut 2016-05-17 01:50
        
        NCSS vs. PHX/WNL vs. SAS - Validation? mittyri 2016-05-18 08:23
        
        Diagnostics ElMaestro 2016-05-18 09:20
        
        Diagnostics: R and Phoenix Helmut 2016-05-18 15:14
        
        Diagnostics: R zizou 2016-05-22 19:07
        
        Diagnostics: R Helmut 2016-05-23 01:22
        
        SASian potpourri d_labes 2016-05-24 12:02
        
        Compilation Helmut 2016-05-24 14:27
        
        REML or not d_labes 2016-05-24 16:33
        
        complete or not Helmut 2016-05-24 16:57
        
        Compilation AngusMcLean 2016-05-26 16:46
        
        doubts about NCSS Helmut 2016-05-26 19:13
        
        Doubts about NCSS zizou 2016-05-26 23:38
        
        Compilation AngusMcLean 2016-05-28 00:51
        
        Kenward-Roger? Helmut 2016-05-28 15:59
        
        90% confidence interval for R_dnm Shuanghe 2019-01-04 17:45
        
        90% confidence interval for R_dnm d_labes 2019-01-05 14:01
        
        Visualizing lmer and limits mittyri 2019-01-06 17:00
        
        Visualizing lmer and limits Shuanghe 2019-01-07 11:05
        Visualizing lmer and limits d_labes 2019-01-07 15:08
        
        Visualizing lmer and limits mittyri 2019-01-13 23:53
        
        90% confidence interval for R_dnm Shuanghe 2019-01-07 10:53
        
        90% confidence interval for R_dnm d_labes 2019-01-07 15:17
        
        90% confidence interval for R_dnm Shuanghe 2019-01-07 17:11
        
        90% confidence interval for R_dnmd_labes 2019-01-07 18:24
        offtop: greek letters and tables mittyri 2019-01-08 00:19
        
        OT: greek letters and symbols Helmut 2019-02-02 16:04
        
        Smith’s paper Helmut 2016-05-18 14:44
        
        Smith’s paper d_labes 2019-01-05 15:00

90% confidence interval for R_dnm [Study As­sess­ment]

Complete thread:

90% confidence interval for R_dnm [Study Assessment]