## Calculation of time above MIC [🇷 for BE/BA]

Dear Aceto81!

It's not implemented in WinNonlin; but I'm right now at a conference in London where one of the lecturers is Jason Chittenden of Pharsight - I will ask him.

I don't know any reference either - except one by Jerome Skelly of the FDA, maybe 20 years ago. Start searching with the term "occupany time" or just "occupancy".

If the values fall below the MIC and come up again (like in your case) do a linear interpolation. An algorithm is like this:

I just made a unchecked hotel-room quickshot in R; 116.5 hr >0.517 ug/ml within 0 - 124 hr?!!

❝ ...I'm struggling with the time above the MIC90 and %time above MIC90.

❝ Prats et al. came up with a time of 102.5 hours and 94.9% of total time in SS.

*Looking*at you data, this seems to be a reasonable value.❝ I have no idea about how to find the 102.5 hours.

❝ I searched in the forum's archive, in the manual of WinNonLin, on the web, but couldn't find any references.

It's not implemented in WinNonlin; but I'm right now at a conference in London where one of the lecturers is Jason Chittenden of Pharsight - I will ask him.

I don't know any reference either - except one by Jerome Skelly of the FDA, maybe 20 years ago. Start searching with the term "occupany time" or just "occupancy".

❝ Maybe someone can give me some help?

❝ I'm routinely use R, but now I'm also using WinNonLin.

If the values fall below the MIC and come up again (like in your case) do a linear interpolation. An algorithm is like this:

- Run a loop through the sampling time points

- If two subsequent concentrations include the MIC and the second one is above, tag an "up" marker

- If two subsequent concentrations include the MIC and the second one is below, tag a "down" marker

- If two subsequent concentrations are >MIC add the time interval to a stack

- If two subsequent concentrations are <MIC goto next concentration

- For the "up" markers perform a linear interpolation to find out where the "line" intersects the MIC;
*subtract*this time value*from the next time point*and add it to the stack

- For the "down" markers perform a linear interpolation to find out where the "line" intersects the MIC;
*add*this time value*to the last time point*and add it to the stack

- Occupancy time = the value of the stack

I just made a unchecked hotel-room quickshot in R; 116.5 hr >0.517 ug/ml within 0 - 124 hr?!!

—

Helmut Schütz

The quality of responses received is directly proportional to the quality of the question asked. 🚮

Science Quotes

*Dif-tor heh smusma*🖖🏼 Довге життя Україна!_{}Helmut Schütz

The quality of responses received is directly proportional to the quality of the question asked. 🚮

Science Quotes

### Complete thread:

- Calculation of time above MIC Aceto81 2008-06-26 16:31 [🇷 for BE/BA]
- Calculation of time above MICHelmut 2008-06-26 18:58
- Calculation of time above MIC Aceto81 2008-06-26 21:50
- Calculation of time above MIC Helmut 2008-06-27 00:18
- Calculation of time above MIC Helmut 2008-06-29 02:24
- Calculation of time above MIC Aceto81 2008-06-30 15:50
- Therapeutic Occupancy Time / MEC Helmut 2008-06-30 16:45

- Calculation of time above MIC Aceto81 2008-06-30 15:50

- Time above MIC (WinNonlin 5.2.1) Helmut 2008-08-08 20:38
- Time above MIC (WinNonlin 5.2.1) Aceto81 2008-08-12 09:56
- Time above MIC (WinNonlin 5.2.1) Helmut 2008-08-12 12:32
- Time above MIC (R function) Aceto81 2008-08-13 11:19
- Time above MIC (R function) Helmut 2008-08-13 13:18
- Time above MIC (R function) Aceto81 2008-08-13 15:35

- Time above MIC (R function) Helmut 2008-08-13 13:18
- Phoenix-WinNonlin 6.0 released 29 May 2009 SDavis 2009-06-04 10:55
- Phoenix-WinNonlin 6.0 Helmut 2009-06-04 11:57
- Phoenix-WinNonlin 6.0 - introductory webinars SDavis 2009-06-04 18:50
- Phoenix-WinNonlin 6.0 - introductory webinars Helmut 2009-06-04 23:40

- Phoenix-WinNonlin 6.0 - introductory webinars SDavis 2009-06-04 18:50

- Phoenix-WinNonlin 6.0 Helmut 2009-06-04 11:57

- Time above MIC (R function) Aceto81 2008-08-13 11:19

- Time above MIC (WinNonlin 5.2.1) Helmut 2008-08-12 12:32
- TimeLow Astea 2017-10-28 22:15
- PHX/WNL 8.0 vs. previous releases Helmut 2017-10-28 23:20
- PHX/WNL 8.0 vs. previous releases Astea 2017-10-28 23:49

- Occupancy, Half Value Duration, Plateau Time in Phoenix/WinNonlin 8 Helmut 2017-10-30 13:18
- Occupancy, Half Value Duration, Plateau Time in Phoenix/WinNonlin 8 Astea 2017-10-31 01:12
- Intersections Helmut 2017-10-31 12:32
- nobody needs it... Astea 2017-10-31 18:24

- Intersections Helmut 2017-10-31 12:32

- Occupancy, Half Value Duration, Plateau Time in Phoenix/WinNonlin 8 Astea 2017-10-31 01:12

- PHX/WNL 8.0 vs. previous releases Helmut 2017-10-28 23:20

- Time above MIC (WinNonlin 5.2.1) Aceto81 2008-08-12 09:56

- Calculation of time above MIC Aceto81 2008-06-26 21:50

- Calculation of time above MICHelmut 2008-06-26 18:58