AUC or Cmax for RSABE? [Power / Sample Size]

posted by BE-proff – Russia, 2018-12-24 17:58  – Posting: # 19714
Views: 826

Hi All,:ok:

let's say I want to conduct a BE study using RSABE (EMA).
From previous studies I have both AUCs and Cmax with their GMR and CVintra.

Which parameter is better for sample size calculation - AUC or Cmax?

Complete thread:

Activity
 Mix view
Bioequivalence and Bioavailability Forum |  Admin contact
19,567 posts in 4,150 threads, 1,340 registered users;
online 12 (0 registered, 12 guests [including 4 identified bots]).
Forum time (Europe/Vienna): 16:24 CEST

Mediocrity knows nothing higher than itself,
but talent instantly recognizes genius.    Arthur Conan Doyle

The BIOEQUIVALENCE / BIOAVAILABILITY FORUM is hosted by
BEBAC Ing. Helmut Schütz
HTML5