Bioequivalence and Bioavailability Forum • estimate(test-ref) in bear

estimate(test-ref) in bear [🇷 for BE/BA]

posted by yjlee168 – Kaohsiung, Taiwan, 2018-12-12 19:58 (1954 d 08:18 ago) – Posting: # 19686
Views: 10,959

Dear mittyri & all others,

❝ ❝ As Yung-jin explained me that PE in R/bear is not a direct arithmetic difference, and it is estimated in a specific linear model in ANOVA.

❝ Sounds strange to me. Do we have the ratio of LSMeans, the ratio of GeoMeans and something else? :confused:

❝ Let's wait for Yung-jin's comments

Estimate(test-ref) in bear is not obtained directly from the difference of mean values or lsmean. It is obtained from one of coefficients of lm() function. I cut the outputs from a test run and show it as follows:

   

---

 Summary Pivotal Parameters of BE Study  

------------------------------------------

 Dependent Variable: log(Cmax)            

------------------------------------------

        n1(R -> T) = 7 

        n2(T -> R) = 7 

          N(n1+n2) = 14 

    Lower criteria = 80.000 %

    Upper criteria = 125.000 %

          MEAN-ref = 7.32951 

         MEAN-test = 7.40146 

               MSE = 0.01780339 

                SE = 0.05043155 

Estimate(test-ref) = 0.07195028 



######  testing  ######

Call:

lm(formula = log(Cmax) ~ seq + subj:seq + prd + drug, data = TotalData, 

    na.action = na.exclude)



Residuals:

     Min       1Q   Median       3Q      Max 

-0.13876 -0.08473  0.00000  0.08473  0.13876 



Coefficients: (14 not defined because of singularities)

            Estimate Std. Error t value Pr(>|t|)    

(Intercept)  7.48268    0.10086  74.187   <2e-16 ***

seq2        -0.06357    0.13343  -0.476   0.6423    

prd2        -0.05095    0.05043  -1.010   0.3323    

drug2        0.07195    0.05043   1.427   0.1792    

...

---

please browse "Interpreting regression coefficient in R" for more details (the explanations for the coefficient x32). Does anyone know the name of this coefficient in statistics? Thanks.

—
All the best,
-- Yung-jin Lee
bear v2.9.1:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan https://www.pkpd168.com/bear
Download link (updated) -> here

Complete thread:

PE vs GMR roman_max 2018-12-10 17:53 [🇷 for BE/BA]
- PE vs GMR Ohlbe 2018-12-11 00:28
  - PE vs GMR roman_max 2018-12-12 16:31
    - PE vs GMR in Bear mittyri 2018-12-12 17:40
      - estimate(test-ref) in bearyjlee168 2018-12-12 18:58
        
        estimate(test-ref) and lsmeans in bear mittyri 2018-12-12 22:57
        
        estimate(test-ref) and lsmeans in bear yjlee168 2018-12-13 12:20
- PE vs GMR mittyri 2018-12-11 16:30
  - PE vs GMR roman_max 2018-12-12 16:41
- PE vs GMR ElMaestro 2018-12-12 21:39
  - PE vs GMR roman_max 2018-12-13 23:11
    - SPSS vs lm mittyri 2018-12-14 15:35
      - SPSS vs lm roman_max 2018-12-15 13:37
        
        SPSS BE code mittyri 2018-12-15 22:07
    - PE vs GMR ElMaestro 2018-12-14 16:11