PE vs GMR [🇷 for BE/BA]

posted by Ohlbe – France, 2018-12-11 01:28 (2042 d 00:36 ago) – Posting: # 19676
Views: 11,629

Dear roman_max,

❝ My question is: does PE and GMR represent different metrics, numerically and/or statistically?


❝ On the one hand GMR by definition is a ratio of LSM T/LSM R

No. This is PE. The GMR is the ratio of geometric means, not of LSM (LSMEAN in SAS-speak). For more details on how to calculate LSM and the difference between LSM and geometric mean, see this oldie.

PE and GMR will be identical if you have a balanced study (same number of subjects in sequence RT and sequence TR). If the study is unbalanced (e.g. if you have a dropout), you'll get different results. The difference is usually minimal, but can be more important if you have an outlier.


Complete thread:

UA Flag
 Admin contact
23,099 posts in 4,857 threads, 1,646 registered users;
107 visitors (0 registered, 107 guests [including 7 identified bots]).
Forum time: 03:04 CEST (Europe/Vienna)

Genius is one per cent inspiration and ninety-nine per cent perspiration.
Accordingly, a ‘genius’ is often merely a talented person
who has done all of his or her homework.    Thomas Alva Edison

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz