PE vs GMR [R for BE/BA]

posted by Ohlbe – France, 2018-12-11 00:28 (649 d 22:04 ago) – Posting: # 19676
Views: 5,764

Dear roman_max,

» My question is: does PE and GMR represent different metrics, numerically and/or statistically?


» On the one hand GMR by definition is a ratio of LSM T/LSM R

No. This is PE. The GMR is the ratio of geometric means, not of LSM (LSMEAN in SAS-speak). For more details on how to calculate LSM and the difference between LSM and geometric mean, see this oldie.

PE and GMR will be identical if you have a balanced study (same number of subjects in sequence RT and sequence TR). If the study is unbalanced (e.g. if you have a dropout), you'll get different results. The difference is usually minimal, but can be more important if you have an outlier.


Complete thread:

 Admin contact
21,068 posts in 4,392 threads, 1,465 registered users;
online 8 (0 registered, 8 guests [including 3 identified bots]).
Forum time: Sunday 23:32 CEST (Europe/Vienna)

Data is not information.
Information is not knowledge.
And knowledge is certainly not wisdom.    Clifford Stoll

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz