## Fieller's Confidence (fiducial) Interval [General Sta­tis­tics]

Dear GM,

» What is the difference between Fieller's Confidence Interval and Locke's Confidence Interval for the ratio of means?
» OR
» Both are same.

The latter.

» We wanted to find the Fieller's Confidence Interval for the ratio of means as mentioned in the below guideline
» ...

Can't see any hint in the direction of Fieller's confidence interval in your posted text.

» Kindly suggest some reference/example related to the clinical endpoint studies.

The mathematical apparatus behind Fieller's Confidence Interval is descibed in
Hauschke D., Kieser M., Diletti E., Burke M.
"SAMPLE SIZE DETERMINATION FOR PROVING EQUIVALENCE BASED ON THE RATIO OF TWO MEANS FOR NORMALLY DISTRIBUTED DATA"
Statist. Med. 18, 93-105 (1999)

Have also a look into R-package PowerTOST, function CI.RatioF().

Regards,

Detlew