Bioequivalence and Bioavailability Forum • Purpose of S:N?

Purpose of S:N? [Bioanalytics]

posted by Helmut – Vienna, Austria, 2018-11-09 13:34 (2225 d 00:46 ago) – Posting: # 19556
Views: 10,238

❝ Is that somewhere stated, that peak height is the signal?

Not only the two references I gave above but all about detection in chromatography since the 1960s.

❝ You need a baseline (whatever that is) to establish this signal (as for the area, so both parameters don't fall out of the clear blue sky but might be considered convention methods, as the PO has noticed). Why not using the same signal as used for calculation of P/A, i.e. most often area? OR ratio of area with IS?

Simple. Given the CDS's settings appropriate to integrate the peak (bunching, smoothing, slope limits for start/end, area threshold) the noise will not be integrated.
BTW, I'm curious how other members of the forum calculate the noise.

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Complete thread:

Isn't it time for an open source chromatographic format ElMaestro 2018-11-04 21:54 [Bioanalytics]
- Isn't it time for an open source chromatographic format nobody 2018-11-05 09:00
  - and now that we are at it ElMaestro 2018-11-05 13:53
    - and now that we are at it nobody 2018-11-05 16:33
      - and now that we are at it ElMaestro 2018-11-05 18:19
    - Transparent ruler – like in the good ol’ days Helmut 2018-11-05 20:39
      - Transparent ruler – like in the good ol’ days Ohlbe 2018-11-05 22:14
        
        Transparent ruler – like in the good ol’ days ElMaestro 2018-11-05 22:43
        
        Slow down, you move too fast […] Feelin’ Groovy Helmut 2018-11-06 02:05
        
        Slow down, you move too fast […] Feelin’ Groovy nobody 2018-11-06 09:29
        
        Yes it went a little fast ElMaestro 2018-11-06 11:09
        
        Yes it went a little fast nobody 2018-11-06 12:05
        
        Yes it went a little fast ElMaestro 2018-11-06 12:10
        
        Yes it went a little fast Helmut 2018-11-07 16:09
        
        Yes it went a little fast ElMaestro 2018-11-07 16:22
        
        Yes it went a little fast nobody 2018-11-07 18:30
        Purpose of S:N? Helmut 2018-11-08 09:46
        
        Purpose of S:N? ElMaestro 2018-11-08 22:27
        
        Purpose of S:N? nobody 2018-11-09 10:06
        
        Purpose of S:N? Helmut 2018-11-09 11:34
        
        Purpose of S:N? nobody 2018-11-09 12:08
        
        Purpose of S:N?Helmut 2018-11-09 12:34
        
        Purpose of S:N? Helmut 2018-11-09 11:26
        
        Purpose of S:N? ElMaestro 2018-11-09 13:16
- Isn't it time for an open source chromatographic format paulhurleyuk 2018-11-05 16:27