Purpose of S:N? [Bioanalytics]

posted by Helmut Homepage – Vienna, Austria, 2018-11-09 13:34 (1966 d 04:51 ago) – Posting: # 19556
Views: 7,019

❝ Is that somewhere stated, that peak height is the signal?


Not only the two references I gave above but all about detection in chromatography since the 1960s.

❝ You need a baseline (whatever that is) to establish this signal (as for the area, so both parameters don't fall out of the clear blue sky but might be considered convention methods, as the PO has noticed). Why not using the same signal as used for calculation of P/A, i.e. most often area? OR ratio of area with IS?


Simple. Given the CDS's settings appropriate to integrate the peak (bunching, smoothing, slope limits for start/end, area threshold) the noise will not be integrated.
BTW, I'm curious how other members of the forum calculate the noise.

Dif-tor heh smusma 🖖🏼 Довге життя Україна! [image]
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

UA Flag
Activity
 Admin contact
22,957 posts in 4,819 threads, 1,638 registered users;
74 visitors (0 registered, 74 guests [including 8 identified bots]).
Forum time: 18:26 CET (Europe/Vienna)

Nothing shows a lack of mathematical education more
than an overly precise calculation.    Carl Friedrich Gauß

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5