Purpose of S:N? [Bioanalytics]

posted by Helmut Homepage – Vienna, Austria, 2018-11-09 11:26 (1418 d 20:40 ago) – Posting: # 19553
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Hi ElMaestro,

» EMA: " (...) the analyte signal of the LLOQ sample should be at least 5 times the signal of a blank sample"

Oh dear, I missed that for years. Biased perception.

» So, it becomes a choice between doing something meaningful or doing something that appears compliant with the guideline :-D

Let me continue my series of methods. Number 3: A/P 10/10% but S:N 3:1. Although I have some doubts whether we can achieve such a nice A/P with such a bad S:N, let it be. I consider this one the "best" of the three. I would never ever use one of the others only cause the S:N is higher.

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