Bioequivalence and Bioavailability Forum

Purpose of S:N? [Bioanalytics]

posted by Helmut  – Vienna, Austria, 2018-11-09 11:26 (1174 d 10:09 ago) – Posting: # 19553
Views: 6,248

Hi ElMaestro,

» EMA: " (...) the analyte signal of the LLOQ sample should be at least 5 times the signal of a blank sample"

Oh dear, I missed that for years. Biased perception.

» So, it becomes a choice between doing something meaningful or doing something that appears compliant with the guideline

Let me continue my series of methods. Number 3: A/P 10/10% but S:N 3:1. Although I have some doubts whether we can achieve such a nice A/P with such a bad S:N, let it be. I consider this one the "best" of the three. I would never ever use one of the others only cause the S:N is higher.

—
Dif-tor heh smusma 🖖
Helmut Schütz


The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

• Isn't it time for an open source chromatographic format ElMaestro 2018-11-04 21:54 [Bioanalytics] 
  • Isn't it time for an open source chromatographic format nobody 2018-11-05 09:00
    • and now that we are at it ElMaestro 2018-11-05 13:53
      • and now that we are at it nobody 2018-11-05 16:33
        • and now that we are at it ElMaestro 2018-11-05 18:19
      • Transparent ruler – like in the good ol’ days Helmut 2018-11-05 20:39
        • Transparent ruler – like in the good ol’ days Ohlbe 2018-11-05 22:14
          • Transparent ruler – like in the good ol’ days ElMaestro 2018-11-05 22:43
            • Slow down, you move too fast […] Feelin’ Groovy Helmut 2018-11-06 02:05
              • Slow down, you move too fast […] Feelin’ Groovy nobody 2018-11-06 09:29
                • Yes it went a little fast ElMaestro 2018-11-06 11:09
                  • Yes it went a little fast nobody 2018-11-06 12:05
                    • Yes it went a little fast ElMaestro 2018-11-06 12:10
                      • Yes it went a little fast Helmut 2018-11-07 16:09
                        • Yes it went a little fast ElMaestro 2018-11-07 16:22
                          • Yes it went a little fast nobody 2018-11-07 18:30
                          • Purpose of S:N? Helmut 2018-11-08 09:46
                            • Purpose of S:N? ElMaestro 2018-11-08 22:27
                              • Purpose of S:N? nobody 2018-11-09 10:06
                                • Purpose of S:N? Helmut 2018-11-09 11:34
                                  • Purpose of S:N? nobody 2018-11-09 12:08
                                    • Purpose of S:N? Helmut 2018-11-09 12:34
                              • Purpose of S:N?Helmut 2018-11-09 11:26
                                • Purpose of S:N? ElMaestro 2018-11-09 13:16
  • Isn't it time for an open source chromatographic format paulhurleyuk 2018-11-05 16:27