## Question：Using Phoenix WinNonlin Crossover object for Tmax test [Nonparametrics]

Dear Helmut Schütz，

When using Phoenix WinNonlin Crossover object for Tmax testing, how can I judge whether it is equivalent by the result?

I read the "The Use Of Non-Parametric Methods In The Statistical Analysis" document（PMID: 4556704）, and I think he is doing the following steps to judge:

1. Determine if the P value of the sequence is greater than 0.05,

2. If the P value of the sequence is less than 0.05, the test of "Treatment" cannot be performed.

3. If the P value of the sequence is greater than 0.05, it is judged whether the P value of the treatment is greater than 0.05.

4. If the P value of the Treatment is greater than the equivalent, otherwise it is not equivalent.

5. If the P value of the sequence and the P value of the Period are both greater than 0.05, a sign test can be used instead of the rank sum test used in the above steps.

Assuming α = 0.05, all of the above P values are the results in the "Effects" table.

Is the above judgment process correct?

If not, what is the correct judgment process?

PARAMETER Test T_stat L_stat p_Value

Tmax Sequence 177.5 0.91791649

Tmax Treatment|(SEQ1=SEQ2) 220 0.021731156

Tmax Period|(SEQ1=SEQ2) 185 0.62428829

Tmax Treatment & Residual (simultaneous) 5.6567621 0.059108471

Best，

0521

When using Phoenix WinNonlin Crossover object for Tmax testing, how can I judge whether it is equivalent by the result?

I read the "The Use Of Non-Parametric Methods In The Statistical Analysis" document（PMID: 4556704）, and I think he is doing the following steps to judge:

1. Determine if the P value of the sequence is greater than 0.05,

2. If the P value of the sequence is less than 0.05, the test of "Treatment" cannot be performed.

3. If the P value of the sequence is greater than 0.05, it is judged whether the P value of the treatment is greater than 0.05.

4. If the P value of the Treatment is greater than the equivalent, otherwise it is not equivalent.

5. If the P value of the sequence and the P value of the Period are both greater than 0.05, a sign test can be used instead of the rank sum test used in the above steps.

Assuming α = 0.05, all of the above P values are the results in the "Effects" table.

Is the above judgment process correct?

If not, what is the correct judgment process?

PARAMETER Test T_stat L_stat p_Value

Tmax Sequence 177.5 0.91791649

Tmax Treatment|(SEQ1=SEQ2) 220 0.021731156

Tmax Period|(SEQ1=SEQ2) 185 0.62428829

Tmax Treatment & Residual (simultaneous) 5.6567621 0.059108471

Best，

0521

### Complete thread:

- Question：Using Phoenix WinNonlin Crossover object for Tmax test - 0521, 2018-11-09 07:02 [Nonparametrics]
- Phoenix WinNonlin Crossover object for Tmax test - mittyri, 2018-11-11 00:21
- Phoenix WinNonlin Crossover object for Tmax test - 0521, 2018-11-11 10:56
- Tmax Hypothesis testing - mittyri, 2018-11-11 23:21
- Tmax Hypothesis testing - 0521, 2018-11-12 07:15
- neglecting periods for Tmax - mittyri, 2018-11-16 22:52

- Tmax Hypothesis testing - 0521, 2018-11-12 07:15

- Tmax Hypothesis testing - mittyri, 2018-11-11 23:21

- Phoenix WinNonlin Crossover object for Tmax test - 0521, 2018-11-11 10:56

- Phoenix WinNonlin Crossover object for Tmax test - mittyri, 2018-11-11 00:21