Question:Using Phoenix WinNonlin Crossover object for Tmax test [Nonparametrics]
Dear Helmut Schütz,
When using Phoenix WinNonlin Crossover object for Tmax testing, how can I judge whether it is equivalent by the result?
I read the "The Use Of Non-Parametric Methods In The Statistical Analysis" document (PMID: 4556704), and I think he is doing the following steps to judge:
1. Determine if the P value of the sequence is greater than 0.05,
2. If the P value of the sequence is less than 0.05, the test of "Treatment" cannot be performed.
3. If the P value of the sequence is greater than 0.05, it is judged whether the P value of the treatment is greater than 0.05.
4. If the P value of the Treatment is greater than the equivalent, otherwise it is not equivalent.
5. If the P value of the sequence and the P value of the Period are both greater than 0.05, a sign test can be used instead of the rank sum test used in the above steps.
Assuming α = 0.05, all of the above P values are the results in the "Effects" table.
Is the above judgment process correct?
If not, what is the correct judgment process?
![[image]](img/uploaded/image541.png)
Best,
0521
When using Phoenix WinNonlin Crossover object for Tmax testing, how can I judge whether it is equivalent by the result?

I read the "The Use Of Non-Parametric Methods In The Statistical Analysis" document (PMID: 4556704), and I think he is doing the following steps to judge:
1. Determine if the P value of the sequence is greater than 0.05,
2. If the P value of the sequence is less than 0.05, the test of "Treatment" cannot be performed.
3. If the P value of the sequence is greater than 0.05, it is judged whether the P value of the treatment is greater than 0.05.
4. If the P value of the Treatment is greater than the equivalent, otherwise it is not equivalent.
5. If the P value of the sequence and the P value of the Period are both greater than 0.05, a sign test can be used instead of the rank sum test used in the above steps.
Assuming α = 0.05, all of the above P values are the results in the "Effects" table.
Is the above judgment process correct?

If not, what is the correct judgment process?

PARAMETER Test T_stat L_stat p_Value
Tmax Sequence 177.5 0.91791649
Tmax Treatment|(SEQ1=SEQ2) 220 0.021731156
Tmax Period|(SEQ1=SEQ2) 185 0.62428829
Tmax Treatment & Residual (simultaneous) 5.6567621 0.059108471
![[image]](img/uploaded/image541.png)
Best,
0521
Complete thread:
- Question:Using Phoenix WinNonlin Crossover object for Tmax test0521 2018-11-09 07:02 [Nonparametrics]
- Phoenix WinNonlin Crossover object for Tmax test mittyri 2018-11-11 00:21
- Phoenix WinNonlin Crossover object for Tmax test 0521 2018-11-11 10:56
- Tmax Hypothesis testing mittyri 2018-11-11 23:21
- Tmax Hypothesis testing 0521 2018-11-12 07:15
- neglecting periods for Tmax mittyri 2018-11-16 22:52
- Tmax Hypothesis testing amritp49 2019-12-18 16:12
- SAP? Helmut 2019-12-18 16:44
- Tmax Hypothesis testing SDavis 2019-12-18 16:52
- Tmax Hypothesis testing 0521 2019-12-18 16:55
- Tmax Hypothesis testing 0521 2018-11-12 07:15
- Tmax Hypothesis testing mittyri 2018-11-11 23:21
- Phoenix WinNonlin Crossover object for Tmax test 0521 2018-11-11 10:56
- Phoenix WinNonlin Crossover object for Tmax test mittyri 2018-11-11 00:21