Yes it went a little fast [Bioanalytics]

posted by nobody – 2018-11-07 18:30 (681 d 21:24 ago) – Posting: # 19544
Views: 4,649

Formally, the limit of detection (LOD) is defined by the S:N ratio. The peak you can definitely distinguish from noise (Limit of blank) with your method. In bioanalytics the LLOQ is by definition the concentration you can determine with P/A of 20%/+/-20% (by a convention method, i.e spiked samples with n=......).

If you (or anybody else in the room...) think your LOD is higher than the LLOQ, you have a problem, in deed. Otherwise... see Helllcourages statement.

Kindest regards, nobody

Complete thread:

Activity
 Admin contact
21,068 posts in 4,392 threads, 1,465 registered users;
online 13 (0 registered, 13 guests [including 8 identified bots]).
Forum time: Saturday 16:54 CEST (Europe/Vienna)

The purpose of models is not to fit the data,
but to sharpen the questions.    Samuel Karlin

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5