Yes it went a little fast [Bioanalytics]

posted by ElMaestro  – Denmark, 2018-11-07 16:22 (852 d 15:02 ago) – Posting: # 19543
Views: 5,103

Hi Helmut,

» IMHO, calculating the S:N is no more than a finger excercise unless required by the method (e.g., traces in accredited environmental analysis where a true blank matrix does not exist).

Yes I think this is my point stated in oher words. There is no universally agreed method to define s:n so as a consequence it is hardly effective or relevant to have a rule about its quantity.

» In bioanalytical methods I'm not sure whether it should be part of an (optional anyway) system suitability test. Playing the devil's advocate - two methods, A/P at the LLOQ 20/20%, S/N 10 or 15/15 5?

I don't follow this terminology, can you explain what you mean? My hindsight is 20/20.
S:N is done at the LLOQ, as far as I know. If it is "good enough" at the LLOQ then it is supposedly also "good enough" (whatever that means) anywhere above the LLOQ.

Pass or fail!
ElMaestro

Complete thread:

Activity
 Admin contact
21,372 posts in 4,463 threads, 1,496 registered users;
online 5 (0 registered, 5 guests [including 3 identified bots]).
Forum time: Tuesday 07:24 CET (Europe/Vienna)

We learn more by looking for the answer to a question and not finding it
than we do from learning the answer itself.    Lloyd Alexander

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5