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Hi Helmut,
Yes I think this is my point stated in oher words. There is no universally agreed method to define s:n so as a consequence it is hardly effective or relevant to have a rule about its quantity.
I don't follow this terminology, can you explain what you mean? My hindsight is 20/20.
S:N is done at the LLOQ, as far as I know. If it is "good enough" at the LLOQ then it is supposedly also "good enough" (whatever that means) anywhere above the LLOQ.
❝ IMHO, calculating the S:N is no more than a finger excercise unless required by the method (e.g., traces in accredited environmental analysis where a true blank matrix does not exist).
Yes I think this is my point stated in oher words. There is no universally agreed method to define s:n so as a consequence it is hardly effective or relevant to have a rule about its quantity.
❝ In bioanalytical methods I'm not sure whether it should be part of an (optional anyway) system suitability test. Playing the devil's advocate - two methods, A/P at the LLOQ 20/20%, S/N 10 or 15/15 5?
I don't follow this terminology, can you explain what you mean? My hindsight is 20/20.
S:N is done at the LLOQ, as far as I know. If it is "good enough" at the LLOQ then it is supposedly also "good enough" (whatever that means) anywhere above the LLOQ.
—
Pass or fail!
ElMaestro
Pass or fail!
ElMaestro
Complete thread:
- Isn't it time for an open source chromatographic format ElMaestro 2018-11-04 21:54 [Bioanalytics]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Isn't it time for an open source chromatographic format nobody 2018-11-05 09:00
- and now that we are at it ElMaestro 2018-11-05 13:53
- and now that we are at it nobody 2018-11-05 16:33
- and now that we are at it ElMaestro 2018-11-05 18:19
- Transparent ruler – like in the good ol’ days Helmut 2018-11-05 20:39
- Transparent ruler – like in the good ol’ days Ohlbe 2018-11-05 22:14
- Transparent ruler – like in the good ol’ days ElMaestro 2018-11-05 22:43
- Slow down, you move too fast […] Feelin’ Groovy Helmut 2018-11-06 02:05
- Slow down, you move too fast […] Feelin’ Groovy nobody 2018-11-06 09:29
- Yes it went a little fast ElMaestro 2018-11-06 11:09
- Yes it went a little fast nobody 2018-11-06 12:05
- Yes it went a little fast ElMaestro 2018-11-06 12:10
- Yes it went a little fast Helmut 2018-11-07 16:09
- Yes it went a little fastElMaestro 2018-11-07 16:22
- Yes it went a little fast nobody 2018-11-07 18:30
- Purpose of S:N? Helmut 2018-11-08 09:46
- Purpose of S:N? ElMaestro 2018-11-08 22:27
- Purpose of S:N? nobody 2018-11-09 10:06
- Purpose of S:N? Helmut 2018-11-09 11:34
- Purpose of S:N? nobody 2018-11-09 12:08
- Purpose of S:N? Helmut 2018-11-09 12:34
- Purpose of S:N? nobody 2018-11-09 12:08
- Purpose of S:N? Helmut 2018-11-09 11:34
- Purpose of S:N? Helmut 2018-11-09 11:26
- Purpose of S:N? ElMaestro 2018-11-09 13:16
- Purpose of S:N? nobody 2018-11-09 10:06
- Purpose of S:N? ElMaestro 2018-11-08 22:27
- Yes it went a little fastElMaestro 2018-11-07 16:22
- Yes it went a little fast Helmut 2018-11-07 16:09
- Yes it went a little fast ElMaestro 2018-11-06 12:10
- Yes it went a little fast nobody 2018-11-06 12:05
- Yes it went a little fast ElMaestro 2018-11-06 11:09
- Slow down, you move too fast […] Feelin’ Groovy nobody 2018-11-06 09:29
- Slow down, you move too fast […] Feelin’ Groovy Helmut 2018-11-06 02:05
- Transparent ruler – like in the good ol’ days ElMaestro 2018-11-05 22:43
- Transparent ruler – like in the good ol’ days Ohlbe 2018-11-05 22:14
- and now that we are at it nobody 2018-11-05 16:33
- and now that we are at it ElMaestro 2018-11-05 13:53
- Isn't it time for an open source chromatographic format paulhurleyuk 2018-11-05 16:27
- Isn't it time for an open source chromatographic format nobody 2018-11-05 09:00
Ing. Helmut Schütz