Bioequivalence and Bioavailability Forum • Yes it went a little fast

Yes it went a little fast [Bioanalytics]

posted by Helmut – Vienna, Austria, 2018-11-07 17:09 (1670 d 21:04 ago) – Posting: # 19542
Views: 6,632

Hi ElMaestro,

IMHO, calculating the S:N is no more than a finger excercise unless required by the method (e.g., traces in accredited environmental analysis where a true blank matrix does not exist). In bioanalytical methods I'm not sure whether it should be part of an (optional anyway) system suitability test. Playing the devil's advocate - two methods, A/P at the LLOQ 20/20%, S/N 10 or 15/15 5?

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

Isn't it time for an open source chromatographic format ElMaestro 2018-11-04 21:54 [Bioanalytics]
- Isn't it time for an open source chromatographic format nobody 2018-11-05 09:00
  - and now that we are at it ElMaestro 2018-11-05 13:53
    - and now that we are at it nobody 2018-11-05 16:33
      - and now that we are at it ElMaestro 2018-11-05 18:19
    - Transparent ruler – like in the good ol’ days Helmut 2018-11-05 20:39
      - Transparent ruler – like in the good ol’ days Ohlbe 2018-11-05 22:14
        
        Transparent ruler – like in the good ol’ days ElMaestro 2018-11-05 22:43
        
        Slow down, you move too fast […] Feelin’ Groovy Helmut 2018-11-06 02:05
        
        Slow down, you move too fast […] Feelin’ Groovy nobody 2018-11-06 09:29
        
        Yes it went a little fast ElMaestro 2018-11-06 11:09
        
        Yes it went a little fast nobody 2018-11-06 12:05
        
        Yes it went a little fast ElMaestro 2018-11-06 12:10
        
        Yes it went a little fastHelmut 2018-11-07 16:09
        
        Yes it went a little fast ElMaestro 2018-11-07 16:22
        
        Yes it went a little fast nobody 2018-11-07 18:30
        Purpose of S:N? Helmut 2018-11-08 09:46
        
        Purpose of S:N? ElMaestro 2018-11-08 22:27
        
        Purpose of S:N? nobody 2018-11-09 10:06
        
        Purpose of S:N? Helmut 2018-11-09 11:34
        
        Purpose of S:N? nobody 2018-11-09 12:08
        
        Purpose of S:N? Helmut 2018-11-09 12:34
        
        Purpose of S:N? Helmut 2018-11-09 11:26
        
        Purpose of S:N? ElMaestro 2018-11-09 13:16
- Isn't it time for an open source chromatographic format paulhurleyuk 2018-11-05 16:27