Yes it went a little fast [Bioanalytics]

posted by ElMaestro  – Denmark, 2018-11-06 11:09 (1054 d 19:41 ago) – Posting: # 19539
Views: 6,042

Hello nobody,


» May I ask what we are doing here? Is this example peak the lowest calibration point? Or do you want to determine s:n for a patient sample (why?)?

This was just a digression.
I asked noone in particular what s:n is and gave a example of a fictive simulated chromatogram on which the forum's experts could practice their skills and demonstrate knowledge.
Shouldn't have done it. But now that you are here, what is in your idea of s:n ? How do you calculate it?

Whether the series respresents an LLOQ or a PK sample or something entirely different is immaterial to this discussion.

So.... what is s:n in your opinion? How would you prefer to quantify the level of noise and the level of signal?

Pass or fail!
ElMaestro

Complete thread:

Activity
 Admin contact
21,700 posts in 4,538 threads, 1,542 registered users;
online 3 (1 registered, 2 guests [including 2 identified bots]).
Forum time: Sunday 07:51 CEST (Europe/Vienna)

A central lesson of science is that to understand complex issues
(or even simple ones), we must try to free our minds of dogma and
to guarantee the freedom to publish, to contradict, and to experiment.
Arguments from authority are unacceptable.    Carl Sagan

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5