## Gutting PowerTOST [R for BE/BA]

Hi Helmut,

» not Detlew but answering anyway.

Thank you for quick reply at every time.

» So why are you not simply using it?
»

library(PowerTOST)» sampleN.RSABE(CV=0.4, theta0=0.9, targetpower=0.8, design="2x2x4")

If you want further information about the arguments and their defaults, type ?sampleN.RSABE in the R-console / R-Studio’s console or consult the online manual.

As this is a replicated study, there are only few articles for calculating the sample size.

I have few more doubts, regarding the terms CVswitch, r_const and pe_constr.

I thought CVswitch=0.30 for both FDA and EMA, r_const=0.25 and 0.760 for FDA and EMA respectively and don't know about the pe_constr.

Kindly correct me if I am wrong...

Best Regards,
GM