About the Partial SS in Boequivalence results in WinNonlin 8.1 [Software]

posted by ElMaestro  – Denmark, 2018-11-01 22:49 (1053 d 05:30 ago) – Posting: # 19518
Views: 3,266

Hi Fyy et al.,

I am not a SAS user or a WNL user, but I think the basis for this question may be a little wrong?

In a 222BE trial the result is generally produced with a linear model, not a mixed model, regardless of authority. In that situation the whole concept of denominator df's if irrelevant. The residual df's will be an integer.

So, I am guessing you fit your model with subject as random, and hence it becomes a mixed model.
If I recall correctly WNL happily fits subject as random by default so one may need to actively tell the beast that everything including subject is fixed. Then the analysis becomes compliant with guidelines and expectation, and there will be no denominator df's to confuse you. :-)

Pass or fail!
ElMaestro

Complete thread:

Activity
 Admin contact
21,691 posts in 4,534 threads, 1,541 registered users;
online 5 (0 registered, 5 guests [including 3 identified bots]).
Forum time: Monday 05:20 CEST (Europe/Vienna)

They were “so intent of making everything numerical”
that they frequently missed seeing
what was there to be seen.    Barbara McClintock

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5