About the Partial SS in Boequivalence results in WinNonlin 8.1 [Software]

posted by ElMaestro  – Belgium?, 2018-11-01 22:49 (687 d 18:36 ago) – Posting: # 19518
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Hi Fyy et al.,

I am not a SAS user or a WNL user, but I think the basis for this question may be a little wrong?

In a 222BE trial the result is generally produced with a linear model, not a mixed model, regardless of authority. In that situation the whole concept of denominator df's if irrelevant. The residual df's will be an integer.

So, I am guessing you fit your model with subject as random, and hence it becomes a mixed model.
If I recall correctly WNL happily fits subject as random by default so one may need to actively tell the beast that everything including subject is fixed. Then the analysis becomes compliant with guidelines and expectation, and there will be no denominator df's to confuse you. :-)

I could be wrong, but...

Best regards,
ElMaestro

R's base package has 274 reserved words and operators, along with 1761 functions. I can use 18 of them (about 14 of them properly). I believe this makes me the Donald Trump of programming.

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