Bioequivalence and Bioavailability Forum

Dear All,
I have some questions about the Partial SS in Bioequivalence results in WinNonlin.

Firstly, why the Partial SS results just provided under default model(2x2x2 design) in WinNonlin 8.1? It just provides the Partial test worksheet in other models. What are the differences and relationship between the Partial test results and Partial SS results?

Secondly, what are the Numer_DF and Denom_DF? What is the calculation method for these DF since it could be decimals in Degrees of freedom sometimes. Just like the following results:

Dependent Units Hypothesis Numer_DF Denom_DF F_stat P_value
Ln(AUClast) int 1 17.863275 2.012866 0.17318289
Ln(AUClast) Sequence 1 17.876226 9.2107972 0.007163829
Ln(AUClast) Formulation 1 17.189233 0.19446307 0.66472393
Ln(AUClast) Period 1 17.202333 0.67862197 0.42133666

Could you kindky help me with these questions?

Thank you very much,

Fu Yangyang

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Edit: Category changed; see also this post #1. [Mittyri]