Bioequivalence and Bioavailability Forum

Dear Friends,

I have problem how to calculate the Cmax1 Cmax2 Cmin Tmax1 Tmax2 and Tmin Auc0-tau1 Auc0-tau2 and Auct in phoenix for each subject.

Here i tried one method
dosing ( dose-20mg/ time of dosing-0/ and tau-24hr)

i got cmin and tmin.... but we manually know that o.oo hr is tmin and BLQ=0.000, so it will be the Cmin.

But sponsor want 1st cmax1 and cmin then again Cmax2. by the same way he want tmax1 and tmin and again tmax2.

kindly give some idea how to solve this

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