An outlier? [Bioanalytics]

posted by Beholder  – Russia, 2018-10-19 09:43 (1140 d 17:55 ago) – Posting: # 19476
Views: 3,480

Hi Helmut and mittyri!

» The link is not working. Can you check?

Please check now. Should work. THX to Moderator.

» Reporting concentrations to six significant digits even more. I assume that the “minimum arithmetic average Cmax” was calculated from different studies; each with a dose of 300 mg.

Looks like the value 1,479.61 ng / ml was taken from PAR of one big Indian pharmaceutical company. I’m not sure that it is average of different studies. BTW, what about seven and even eight significant digits (see PAR, pg 20)?:-D

» In the analyzed studies, the minimum value of Cmax was 60.8 ng / ml,

IMHO, that is actually the case. According to the article (Table 1), only 300 mg and 400 mg doses (not strengths) were included to the analysis. So looks like 60.8 ng / ml is an outlier due to extreme fast metabolizing?

Best regards
Beholder

Complete thread:

Activity
 Admin contact
21,785 posts in 4,556 threads, 1,547 registered users;
online 11 (0 registered, 11 guests [including 10 identified bots]).
Forum time: Friday 02:38 CET (Europe/Vienna)

A drug is that substance which, when injected into a rat,
will produce a scientific report.    Anonymous

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5