Bioequivalence and Bioavailability Forum

Avoid raw residuals [General Sta­tis­tics]

posted by Helmut  – Vienna, Austria, 2018-10-18 19:14 (2344 d 06:40 ago) – Posting: # 19470
Views: 16,398

Hi Rosy,

❝ I know, what's wrong with my regulation, anyway... that's because I'm Mexican (if you remember Guillermo del Toro speach) LOL

 This part?

❝ I will try to follow you directions on phoenix, …

Good luck.

❝ … but someone tell me that it's valid to make a linear regression between Ln_observed and predicted from "Residuals" output from Phoenix

What? That’s not interesting because it is rather difficult to “see” anything useful.*
You could plot the residuals (y) vs. Ln_predicted (x). Cave: In a 2×2 crossover for every subject you have two residuals with opposite signs. You need only one of them (commonly the first period is used). However, raw residuals are not very useful. Though you get an idea about trends (if they increase/decrease or show a strange shape the model is wrong) or homo-/heteroscedasticity (funnel shape) their magnitude is not telling. That’s why you should standardize/studentize them.

❝ … and obtain the Student residuals to find outliers, is that right?

Yep. Though I would not call them outliers (regulators don’t like it) but “aberrant values”.

---

• That’s why in comparing two bioanalytical methods nobody plots method 1 / method 2 but uses the Bland-Altman plot.

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна! 
Helmut Schütz


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Complete thread:

• Qualitative analysis of the ANOVA residuals Lucas 2014-02-19 14:27 [General Sta­tis­tics] 
  • Qualitative analysis of the ANOVA residuals Helmut 2014-02-19 15:22
    • Qualitative analysis of the ANOVA residuals Lucas 2014-02-19 15:58
      • Qualitative analysis of the ANOVA residuals Helmut 2014-02-19 16:25
        • Qualitative analysis of the ANOVA resid­uals Lucas 2014-02-19 17:20
        • Qualitative analysis of the ANOVA resid­u­als Lucas 2014-02-20 19:07
          • First hints for Phoenix Helmut 2014-02-20 20:11
          • Phoenix: resid­u­als Helmut 2014-02-21 19:25
            • Phoenix: resid­u­als BRN 2014-03-04 15:15
              • Phoenix: resid­u­als Helmut 2014-03-04 16:52
            • Phoenix: resid­u­als Rosy 2018-10-15 07:03
              • Software validation Helmut 2018-10-15 11:43
                • Software validation Rosy 2018-10-18 00:38
                  • Avoid raw residualsHelmut 2018-10-18 17:14
                    • Avoid raw residuals Rosy 2018-10-18 18:05
          • Phoenix → R Helmut 2014-02-23 02:20
            • Phoenix → R Lucas 2014-02-25 19:28
  • Qualitative analysis of the ANOVA residuals ElMaestro 2014-02-19 15:32
    • Qualitative analysis of the ANOVA residuals Helmut 2014-02-19 16:06
    • Qualitative analysis of the ANOVA residuals Lucas 2014-02-19 16:13
      • Qualitative analysis of the ANOVA resid­u­als ElMaestro 2014-02-19 20:40