Subject exclusion [Outliers]

posted by Helmut Homepage – Vienna, Austria, 2018-10-02 21:27 (876 d 05:26 ago) – Posting: # 19406
Views: 4,620

Salam Mohamed,

first of all: Please follow the Forum’s Policy about avoiding TOFU. THX.

» ;-) ok we will wait

In principle I agree with Ohlbe. But IMHO, “the subject didn’t swallow the drug” is not the only reason behind this statement in the GL. IIRC, this topic appeared for the first time in Rev.1 of the PKWP’s Q&A document in a section about omeprazole (updated in Rev.2, deleted in Rev.12). Esp. old – monolithic – gastric resistant PPI-formulations had problems with the coating. If you dive deeper into this issue you will face further questions, e.g.,

Dif-tor heh smusma 🖖
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

Activity
 Admin contact
21,355 posts in 4,458 threads, 1,493 registered users;
online 5 (0 registered, 5 guests [including 5 identified bots]).
Forum time: Thursday 02:54 UTC (Europe/Vienna)

The rise of biometry in this 20th century,
like that of geometry in the 3rd century before Christ,
seems to mark out one of the great ages or critical periods
in the advance of the human understanding.    R.A. Fisher

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5