Subject exclusion [Outliers]

posted by Helmut Homepage – Vienna, Austria, 2018-10-02 23:27 (1031 d 04:38 ago) – Posting: # 19406
Views: 5,028

Salam Mohamed,

first of all: Please follow the Forum’s Policy about avoiding TOFU. THX.

» ;-) ok we will wait

In principle I agree with Ohlbe. But IMHO, “the subject didn’t swallow the drug” is not the only reason behind this statement in the GL. IIRC, this topic appeared for the first time in Rev.1 of the PKWP’s Q&A document in a section about omeprazole (updated in Rev.2, deleted in Rev.12). Esp. old – monolithic – gastric resistant PPI-formulations had problems with the coating. If you dive deeper into this issue you will face further questions, e.g.,

Dif-tor heh smusma 🖖
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

Activity
 Admin contact
21,592 posts in 4,514 threads, 1,532 registered users;
online 12 (0 registered, 12 guests [including 4 identified bots]).
Forum time: Friday 04:05 CEST (Europe/Vienna)

It is a capital mistake to theorise before one has data.    Arthur Conan Doyle

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5