Subject exclusion [Outliers]

posted by Helmut Homepage – Vienna, Austria, 2018-10-03 01:27 (2004 d 00:01 ago) – Posting: # 19406
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Salam Mohamed,

first of all: Please follow the Forum’s Policy about avoiding TOFU. THX.

;-) ok we will wait


In principle I agree with Ohlbe. But IMHO, “the subject didn’t swallow the drug” is not the only reason behind this statement in the GL. IIRC, this topic appeared for the first time in Rev.1 of the PKWP’s Q&A document in a section about omeprazole (updated in Rev.2, deleted in Rev.12). Esp. old – monolithic – gastric resistant PPI-formulations had problems with the coating. If you dive deeper into this issue you will face further questions, e.g.,

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