Subject exclusion [Outliers]

posted by Mohamed Yehia  – Egypt, 2018-10-03 00:18 (2089 d 13:51 ago) – Posting: # 19400
Views: 7,013

Dear Ohlbe,

❝ The guideline does not ask for any statistical outlier test to be performed. If you have a subject with very low concentrations, calculate the geometric mean of the AUC of the reference without that subject. If the AUC of the subject for the reference product is lower than 5 % of that mean you have a possibility to exclude him. That's all.


It is stated that we have to remove outlier subjects for reference auc before making th geometric mean calculation. So I think that we have to include all the subjects inckuding the one we want to check and check for the outlier first and in case there is no outlier we then calculate the geometric mean and check for 5 %.


Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post! [Ohlbe]

Complete thread:

UA Flag
Activity
 Admin contact
23,059 posts in 4,841 threads, 1,648 registered users;
36 visitors (0 registered, 36 guests [including 10 identified bots]).
Forum time: 14:09 CEST (Europe/Vienna)

There are only two kinds of scholars;
those who love ideas and those who hate them.    Emile Chartier

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5