Subject exclusion [Outliers]

posted by Mohamed Yehia  – Egypt, 2018-10-02 23:25 (2373 d 11:30 ago) – Posting: # 19395
Views: 9,057

Hi All,

Concerning what stated in EMEA guidelines, if auc of reference cmax of certain subject is less than 5% of the geometric mean, the subject is excluded.

My question is: when we calculate the geometric mean of the reference auc, shall we include the subject we want to inspect in the calculation of the geometric mean or we shall remove it first before making the calculation?

Thanks.


Edit: Category changed; see also this post #1[Helmut]

Complete thread:

UA Flag
Activity
 Admin contact
23,411 posts in 4,922 threads, 1,666 registered users;
59 visitors (0 registered, 59 guests [including 10 identified bots]).
Forum time: 10:56 CEST (Europe/Vienna)

Statistic – A subject which most statisticians find difficult
but in which nearly all physicians are expert.    Stephen Senn

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5