FDA Recommendation on Matrix Effect Determination in CC Assay [Bioanalytics]

posted by ElMaestro  – Denmark, 2018-10-01 18:30 (2467 d 17:05 ago) – Posting: # 19355
Views: 3,839

Hello both,

is there any method published anywhere which can be realistically thought to have no matrix effect?
Not just absence of mentioned effect, but truly verified absence of one and how would one go about proving it?

If you had a gun pointed to your head and someone asks you to develop an LC-MS/MS method without matrix effect for, say, Duloxetine or Simvastatin where would you start?

Pass or fail!
ElMaestro

Complete thread:

UA Flag
Activity
 Admin contact
23,427 posts in 4,929 threads, 1,678 registered users;
71 visitors (0 registered, 71 guests [including 44 identified bots]).
Forum time: 11:35 CEST (Europe/Vienna)

Half the harm that is done in this world
Is due to people who want to feel important.    T. S. Eliot

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5