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RegisterFDA Recommendation on Matrix Effect Determination in CC Assay [Bioanalytics]
Hello both,
is there any method published anywhere which can be realistically thought to have no matrix effect?
Not just absence of mentioned effect, but truly verified absence of one and how would one go about proving it?
If you had a gun pointed to your head and someone asks you to develop an LC-MS/MS method without matrix effect for, say, Duloxetine or Simvastatin where would you start?
is there any method published anywhere which can be realistically thought to have no matrix effect?
Not just absence of mentioned effect, but truly verified absence of one and how would one go about proving it?
If you had a gun pointed to your head and someone asks you to develop an LC-MS/MS method without matrix effect for, say, Duloxetine or Simvastatin where would you start?
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Pass or fail!
ElMaestro
Pass or fail!
ElMaestro
Complete thread:
- FDA Recommendation on Matrix Effect Determination in CC Assay Obinoscopy 2018-10-01 14:38 [Bioanalytics]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- FDA Recommendation on Matrix Effect Determination in CC Assay Ohlbe 2018-10-01 15:30
- FDA Recommendation on Matrix Effect Determination in CC AssayElMaestro 2018-10-01 16:30
- Reducing matrix effects Ohlbe 2018-10-01 17:20
- FDA Recommendation on Matrix Effect Determination in CC AssayElMaestro 2018-10-01 16:30
- FDA Recommendation on Matrix Effect Determination in CC Assay Ohlbe 2018-10-01 15:30
Ing. Helmut Schütz