FDA Recommendation on Matrix Effect Determination in CC Assay [Bioanalytics]

posted by ElMaestro  – Belgium?, 2018-10-01 16:30 (721 d 23:05 ago) – Posting: # 19355
Views: 1,885

Hello both,

is there any method published anywhere which can be realistically thought to have no matrix effect?
Not just absence of mentioned effect, but truly verified absence of one and how would one go about proving it?

If you had a gun pointed to your head and someone asks you to develop an LC-MS/MS method without matrix effect for, say, Duloxetine or Simvastatin where would you start?

I could be wrong, but...

Best regards,
ElMaestro

R's base package has 274 reserved words and operators, along with 1761 functions. I can use 18 of them (about 14 of them properly). I believe this makes me the Donald Trump of programming.

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