Calculation of AUC0-72 [NCA / SHAM]

posted by Ohlbe – France, 2008-06-10 19:28 (6165 d 08:26 ago) – Posting: # 1935
Views: 33,129

Dear all,

❝ ❝ How many minimum concentrations requried for calculation of t1/2 and Kel.

❝

❝ For the estimation of kel 3, for the calculation of t1/2 zero. SCNR :-D


What is the point in calculating kel and t½, if you are using truncated AUC ?

If you are truncating your AUC at 72 h, it probably means that you have a drug with a long terminal half-life. The points you have till 72 hours may not be sufficient and adequate to provide a reliable estimate of kel.

Regards
Ohlbe

Complete thread:

UA Flag
Activity
 Admin contact
23,424 posts in 4,927 threads, 1,669 registered users;
25 visitors (0 registered, 25 guests [including 9 identified bots]).
Forum time: 03:55 CEST (Europe/Vienna)

There are two possible outcomes: if the result confirms the
hypothesis, then you’ve made a measurement. If the result is
contrary to the hypothesis, then you’ve made a discovery.    Enrico Fermi

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5