Bioequivalence and Bioavailability Forum

Calculation of AUC0-72 [NCA / SHAM]

posted by Jaime_R – Barcelona, 2008-06-10 14:18 (6219 d 13:22 ago) – Posting: # 1934
Views: 35,574

Hi Sasi!

❝ ... i need to calculate AUC0-72 instead of AUClast and AUCinf how can i calculate this value by using winnonlin.

I'm not sure whether I understand your question.

• If your study was planned to be evaluated with AUC_0-72 as the primary target parameter, I would expect that your last sampling time point was 72 hours - therefore AUC_0-72 = AUC_last.
  
• If you have sampled for a longer time period and later on changed your mind (why?), you have to exclude these time points from calculations:
  Assuming your sampling times are contained in a column named 'time' > click this column once > Data > Exclude > Criteria >
  Write '72' in the field 'Find'
  In the 'Search Area' select the second option 'Column: time'
  In the 'Operation' field select '>'
  Check [x] the box 'Exclude Row Matching Criteria'
  Click 'Exclude'
  Then proceed as usual in th BE-wiz.

❝ How many minimum concentrations requried for calculation of t1/2 and Kel.

For the estimation of k_el 3, for the calculation of t_½ zero. SCNR

Complete thread:

• Calculation of AUC0-72 Sasi 2008-06-10 10:44 [NCA / SHAM] 
  • Calculation of AUC0-72Jaime_R 2008-06-10 12:18
    • Calculation of AUC0-72 Ohlbe 2008-06-10 17:28
      • Calculation of AUC0-72 Jaime_R 2008-06-10 18:45
        • Regulators truncated d_labes 2009-06-18 09:26
          • Regulators truncated Ohlbe 2009-06-18 10:37
          • Regulators truncated Helmut 2009-06-18 14:49
            • Regulators truncated d_labes 2009-06-18 15:26
              • Regulators truncated Helmut 2009-06-18 15:44
                • Regulators truncated ElMaestro 2009-06-19 22:16
                  • Regulators truncated Helmut 2009-06-19 22:35
          • Luke 23:34 ElMaestro 2009-06-18 14:50
      • Calculation of AUC0-72 d_labes 2008-09-05 15:00
        • Calculation of AUC0-72 Helmut 2009-01-26 16:24
          • Calculation of AUC0-72 d_labes 2009-01-26 16:57
            • Calculation of AUC0-72 Helmut 2009-01-26 17:20
              • The missing 72h d_labes 2009-01-27 11:48
                • The missing 72h Ohlbe 2009-01-28 00:00
                  • sensitivity analyses ? martin 2009-01-28 08:26
                  • Regulators ways are inscrutable d_labes 2009-01-28 09:54
                    • Regulators ways are inscrutable (at least the French) Ohlbe 2009-01-28 10:16
                • The missing 72h ElMaestro 2009-01-28 14:32
                  • Page 3848 of 221 d_labes 2009-01-28 14:51
                • Partial AUC calculation Astea 2017-03-11 20:14
                  • Partial AUC calculation mittyri 2017-03-16 19:46
  • Calculation of AUC0-72 PharmCat 2022-12-21 20:49