Group Effect in Full Replicate Design [RSABE / ABEL]
Dear Helmut,
Thank you very much for the clarification. One more last question...
But as per Progesterone Guidance, Treatment as random term in Average BE.
Please see model SAS code from guidance.
MODEL LAUCT = SEQ PER TRT/ DDFM=SATTERTH;
RANDOM TRT/TYPE=FA0(2) SUB=SUBJ G;
As per your version, Subject (nested within Group × Sequence) is the random term.
Now am Confused,Which is the correct one?
Thank you very much for the clarification. One more last question...
❝ ❝ ❝ Honestly, I have no clue how to modify the models given in the progesterone-guidance.
❝
❝ Specifically the scaling-part…
❝ For the ABE part (if swR <0.294) like the FDA’s Model II:
- fixed:
❝ Group, Sequence, Treatment, Period (nested within Group), Group-by-Sequence Interaction
❝
- random:
❝ Subject (nested within Group × Sequence)
But as per Progesterone Guidance, Treatment as random term in Average BE.
Please see model SAS code from guidance.
MODEL LAUCT = SEQ PER TRT/ DDFM=SATTERTH;
RANDOM TRT/TYPE=FA0(2) SUB=SUBJ G;
As per your version, Subject (nested within Group × Sequence) is the random term.
Now am Confused,Which is the correct one?
—
Best Regards,
GM
Best Regards,
GM
Complete thread:
- Group Effect in Full Replicate Design GM 2018-09-12 07:17 [RSABE / ABEL]
- Group Effect in Full Replicate Design Helmut 2018-09-12 11:20
- Group Effect in Full Replicate Design GM 2018-09-12 12:32
- Group Effect in Full Replicate Design Helmut 2018-09-12 13:08
- Group Effect in Full Replicate Design GM 2018-09-12 13:23
- Group Effect in Full Replicate Design Helmut 2018-09-12 15:09
- Group Effect in Full Replicate DesignGM 2018-09-12 15:19
- Group Effect in Full Replicate Design Helmut 2018-09-12 15:31
- Group Effect in Replicate Design zizou 2018-09-12 23:30
- Group Effect in Replicate Design Helmut 2018-09-13 11:34
- Group Effect in Replicate Design zizou 2018-09-12 23:30
- Group Effect in Full Replicate Design Helmut 2018-09-12 15:31
- Group Effect in Full Replicate DesignGM 2018-09-12 15:19
- Group Effect in Full Replicate Design Helmut 2018-09-12 15:09
- Group Effect in Full Replicate Design GM 2018-09-12 13:23
- Group Effect in Full Replicate Design Helmut 2018-09-12 13:08
- Group Effect in Full Replicate Design GM 2018-09-12 12:32
- Group Effect in Full Replicate Design Helmut 2018-09-12 11:20