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RegisterGroup Effect in Full Replicate Design [RSABE / ABEL]
posted by Helmut 
– Vienna, Austria, 2018-09-12 17:09 (2469 d 17:12 ago) – Posting: # 19276
Views: 8,121
Hi Gm,
Very good.
Again: you have to include “group” as a factor in various ways (see below).
As I wrote above
Specifically the scaling-part…
For the ABE part (if swR <0.294) like the FDA’s Model II:
❝ We don't want to take any decisions on the basis of model terms.
Very good.
❝ Our thought is, we need to check group effect for both ABE and RSABE also.
Again: you have to include “group” as a factor in various ways (see below).
❝ If this correct, how the model is to be designed for RSABE?
As I wrote above
❝ ❝ Honestly, I have no clue how to modify the models given in the progesterone-guidance.
Specifically the scaling-part…
For the ABE part (if swR <0.294) like the FDA’s Model II:
- fixed:
Group, Sequence, Treatment, Period (nested within Group), Group-by-Sequence Interaction
- random:
Subject (nested within Group × Sequence)
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Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Complete thread:
- Group Effect in Full Replicate Design GM 2018-09-12 07:17 [RSABE / ABEL]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Group Effect in Full Replicate Design Helmut 2018-09-12 11:20
- Group Effect in Full Replicate Design GM 2018-09-12 12:32
- Group Effect in Full Replicate Design Helmut 2018-09-12 13:08
- Group Effect in Full Replicate Design GM 2018-09-12 13:23
- Group Effect in Full Replicate DesignHelmut 2018-09-12 15:09
- Group Effect in Full Replicate Design GM 2018-09-12 15:19
- Group Effect in Full Replicate Design Helmut 2018-09-12 15:31
- Group Effect in Replicate Design zizou 2018-09-12 23:30
- Group Effect in Replicate Design Helmut 2018-09-13 11:34
- Group Effect in Replicate Design zizou 2018-09-12 23:30
- Group Effect in Full Replicate Design Helmut 2018-09-12 15:31
- Group Effect in Full Replicate Design GM 2018-09-12 15:19
- Group Effect in Full Replicate DesignHelmut 2018-09-12 15:09
- Group Effect in Full Replicate Design GM 2018-09-12 13:23
- Group Effect in Full Replicate Design Helmut 2018-09-12 13:08
- Group Effect in Full Replicate Design GM 2018-09-12 12:32
- Group Effect in Full Replicate Design Helmut 2018-09-12 11:20
Ing. Helmut Schütz