f2 computation (for pts > 85%) [Dissolution / BCS / IVIVC]

posted by jag009  – NJ, 2018-09-12 00:00 (1172 d 01:09 ago) – Posting: # 19262
Views: 3,774

» » One question related to f2 computation... According to guidance you only include one pt after 85 % release. But for drugs that don't show plateau after 85% (ie; even at one pt after 85%, the curve is still climbing) you have to include addition points right?
»
» Where does that concept come from? And could you put more words to it?
» Also, I am thinking a plateau is something which is hard to debate in a purely measurable way.
»
» Muy confundido :confused:

NOT me! My boss said so... I was wondering too.
Does it matter if the drug is an ER or IR?

Thx
John

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