f2 computation (for pts > 85%) [Dissolution / BCS / IVIVC]

posted by jag009  – NJ, 2018-09-11 22:00 (771 d 02:22 ago) – Posting: # 19262
Views: 3,118

» » One question related to f2 computation... According to guidance you only include one pt after 85 % release. But for drugs that don't show plateau after 85% (ie; even at one pt after 85%, the curve is still climbing) you have to include addition points right?
»
» Where does that concept come from? And could you put more words to it?
» Also, I am thinking a plateau is something which is hard to debate in a purely measurable way.
»
» Muy confundido :confused:

NOT me! My boss said so... I was wondering too.
Does it matter if the drug is an ER or IR?

Thx
John

Complete thread:

Activity
 Admin contact
21,174 posts in 4,412 threads, 1,477 registered users;
online 6 (0 registered, 6 guests [including 5 identified bots]).
Forum time: Thursday 00:22 UTC (Europe/Vienna)

It is not so much that I have confidence in scientists being right,
but that I have so much in nonscientists being wrong.    Isaac Asimov

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5