f2 computation (for pts > 85%) [Dissolution / BCS / IVIVC]

posted by ElMaestro  – Denmark, 2018-09-11 00:52 (2345 d 02:46 ago) – Posting: # 19258
Views: 5,655

Hi jag,

❝ One question related to f2 computation... According to guidance you only include one pt after 85 % release. But for drugs that don't show plateau after 85% (ie; even at one pt after 85%, the curve is still climbing) you have to include addition points right?


Where does that concept come from? And could you put more words to it?
Also, I am thinking a plateau is something which is hard to debate in a purely measurable way.

Muy confundido :confused:

Pass or fail!
ElMaestro

Complete thread:

UA Flag
Activity
 Admin contact
23,379 posts in 4,913 threads, 1,661 registered users;
266 visitors (0 registered, 266 guests [including 15 identified bots]).
Forum time: 02:39 CET (Europe/Vienna)

Statistics is the art of never having to say you’re wrong.
Variance is what any two statisticians are at.    C.J. Bradfield

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5