f2 computation (for pts > 85%) [Dissolution / BCS / IVIVC]

posted by ElMaestro  – Denmark, 2018-09-10 22:52 (946 d 16:06 ago) – Posting: # 19258
Views: 3,634

Hi jag,

» One question related to f2 computation... According to guidance you only include one pt after 85 % release. But for drugs that don't show plateau after 85% (ie; even at one pt after 85%, the curve is still climbing) you have to include addition points right?

Where does that concept come from? And could you put more words to it?
Also, I am thinking a plateau is something which is hard to debate in a purely measurable way.

Muy confundido :confused:

Pass or fail!
ElMaestro

Complete thread:

Activity
 Admin contact
21,417 posts in 4,475 threads, 1,508 registered users;
online 13 (0 registered, 13 guests [including 2 identified bots]).
Forum time: Wednesday 14:58 CEST (Europe/Vienna)

Old beliefs die hard
even when demonstrably false.    E. O. Wilson

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5