f2 computation (for pts > 85%) [Dissolution / BCS / IVIVC]

posted by ElMaestro  – Denmark, 2018-09-11 00:52 (2486 d 06:41 ago) – Posting: # 19258
Views: 6,107

Hi jag,

❝ One question related to f2 computation... According to guidance you only include one pt after 85 % release. But for drugs that don't show plateau after 85% (ie; even at one pt after 85%, the curve is still climbing) you have to include addition points right?


Where does that concept come from? And could you put more words to it?
Also, I am thinking a plateau is something which is hard to debate in a purely measurable way.

Muy confundido :confused:

Pass or fail!
ElMaestro

Complete thread:

UA Flag
Activity
 Admin contact
23,425 posts in 4,928 threads, 1,676 registered users;
67 visitors (0 registered, 67 guests [including 9 identified bots]).
Forum time: 07:33 CEST (Europe/Vienna)

No problem can stand the assault of sustained thinking.    Voltaire

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5