f2 computation (for pts > 85%) [Dissolution / BCS / IVIVC]

posted by ElMaestro  – Denmark, 2018-09-10 22:52 (860 d 06:18 ago) – Posting: # 19258
Views: 3,478

Hi jag,

» One question related to f2 computation... According to guidance you only include one pt after 85 % release. But for drugs that don't show plateau after 85% (ie; even at one pt after 85%, the curve is still climbing) you have to include addition points right?

Where does that concept come from? And could you put more words to it?
Also, I am thinking a plateau is something which is hard to debate in a purely measurable way.

Muy confundido :confused:

Pass or fail!

Complete thread:

 Admin contact
21,303 posts in 4,441 threads, 1,487 registered users;
online 5 (0 registered, 5 guests [including 3 identified bots]).
Forum time: Monday 04:10 CET (Europe/Vienna)

I believe there is no philosophical high-road in science,
with epistemological signposts. No, we are in a jungle
and find our way by trial and error,
building our road behind us as we proceed.    Max Born

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz