Bioequivalence and Bioavailability Forum 06:55 CET

Main page Policy/Terms of Use Abbreviations Latest Posts

 Log in |  Register |  Search

recoveries more than 100% [Bioanalytics]

posted by deepakpangavhane - India, 2018-09-03 08:28  - Posting: # 19205
Views: 803

Hi everyone!

The % recovery was 107.80%, 112.65% and 105.92% for the low quality control (LQC) and middle quality controls (MQC2 and MQC1), respectively. Whereas % recovery for higher quality control (HQC) was 98.25%.

The % recovery was determined by comparing the mean peak area of 6 replicates of extracted quality control samples at High, Middle and Low concentrations against respective mean peak area of 6 replicates of un-extracted quality control samples at High, Middle and Low concentrations. Internal standard used was deuterated.

Kindly confirm recoveries markedly higher than 100% for LQC, MQC2 and MQC1 are acceptable as per USFDA guidelines?? Also specify reason for higher recoveries.

Complete thread:

Activity
 Mix view
Bioequivalence and Bioavailability Forum |  Admin contact
18,933 posts in 4,039 threads, 1,288 registered users;
online 13 (0 registered, 13 guests [including 9 identified bots]).

There are no such things as applied sciences,
only applications of science.    Louis Pasteur

The BIOEQUIVALENCE / BIOAVAILABILITY FORUM is hosted by
BEBAC Ing. Helmut Schütz
HTML5 RSS Feed